OWEGO, NY – GI Cryo, Inc a start-up med tech company focused on developing and commercializing novel cryoablation technology platform to treat pancreatic cancer and other gastrointestinal related cancers, announced today that John M. Baust, PhD will deliver a corporate presentation at the Boston Oncology Investor Conference 2019 on Friday, March 15 at 9:35 AM ET. The event will take place at 28 State Street, Boston, MA. Visit www.gicryo.us to learn more about the FrostBite technology platform.
Information about the Boston Oncology Investor Conference 2019 can be found at www.oncologyinvestorconference.com. GI Cryo has partnered with CPSI Biotech to bring the innovative GastroCS and FrostBite EUS Cryocatheter cryoablation platform to commercialization.
Click Here to read the full Press Release: GI Cryo to Present on its Pancreatic Cancer Cryoablation Technology at the Boston Oncology Investor Conference 2019
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OWEGO, NY – CPSI Biotech announced today the publication of a peer-reviewed article detailing the potential benefit of the combination of heat (hyperthermia) and freezing (cryoablation) based ablation strategies for the targeting of pancreatic cancer. The study, titled Dual Thermal Ablation of Pancreatic Cancer Cells as an Improved Combinatorial Treatment Strategy, published as an open access article in the journal Liver and Pancreatic Sciences, was a multi-institutional collaboration between researchers from CPSI and Binghamton University.
The article details the impact of treating pancreatic cancer cells using two ablative strategies, cryo and hyperthermic ablation, used clinically to treat pancreatic as well as other cancers. One arm of the study investigated the impact of the combined application of these ablative treatments strategies on pancreatic cancer in an in vitro cell model. The data show that the combination of exposing cancer cells to heat based ablation followed by freezing results in increased cell death compared to when either is applied as a single exposure (mono) therapy. Commenting on the article, Dr. John M. Baust (President and Lead Scientist, CPSI Biotech) stated “this study demonstrates that ablative therapies provide for an effective means of destroying pancreatic cancer cells. These initial findings from this in vitro suggest that further investigation into the use of a dual thermal ablation regime for treating pancreatic cancer is warranted.”
This study was conducted as part of CPSI’s ongoing research and technology development program focused on the development of a next generation cryoablation device (FrostBite™) and approach for the treatment of pancreatic cancer. The initial development efforts behind FrostBite™ and the DTA study have been supported, in part, by a Phase I and II SBIR grant awarded to CPSI by the National Cancer Institute. Ongoing efforts at CPSI continue to build upon this success and are focusing on further development, optimization and testing of FrostBite™ for the treatment of pancreatic cancer as well as other gastroenterological (GI) based cancers. With development underway, CPSI is poised to embark down the commercialization path. To this end, Dr. John M. Baust commented “We are actively seeking investors and partners to join our team to bring this potentially lifesaving technology platform to the market.” To enable this, a start-up company (GI Cryo, Inc.) has been formed focused in the GI area to commercialize FrostBite™ and other related technologies.
The open access article, initially published online November 30th , is timely in view of the recent increased interest in use of cryoablation for the treatment of cancer and can be accessed free of charge via the Liver and Pancreatic Science website at http://www.oatext.com/Dual-thermal-ablation-of-pancreatic-cancer-cells-as-an-improved-combinatorial-treatment-strategy.php#Article.
Click Here to read the full Press Release: Combinatorial Ablative Strategies Yield Improved Destruction of Pancreatic Cancer Cells
More information on FrostBite™ or any of CPSI’s other technologies is available on CPSI Biotech’s website www.cpsibiotech.com.
Owego, NY – CPSI Biotech (CPSI) announced today it has been awarded a Phase II Small Business Innovation Research (SBIR) grant from the National Cancer Institute (NCI) of the National Institutes of Health (NIH). The 2 year $1.7 million Phase II project focuses on the development of a next generation cryoablation device (FrostBite™) and approach for the treatment of pancreatic cancer.
Dr. John Baust (CPSI President) commented “the overall objective of FrostBite™ is to provide a powerful ablative tool to attack pancreatic cancer, which ultimately may reduce our reliance on other traditional approaches such as chemotherapy, radiation or major surgery to treat this deadly disease.” The potential impact of the technology is tremendous. Speaking about the technology, Dr. P. Jay Pasricha (Professor of Medicine and Neurosciences, Division of Gastroenterology, John Hopkins School of Medicine and consultant for CPSI) commented “We are very encouraged by the potential of FrostBite™ EUS-cryocatheter platform. The ability to target and freeze tissues in situ under endoscopic ultrasound guidance will provide for a more precise and minimally invasive strategy to treat cancer including pancreatic, esophageal and other tumors. We are looking forward to continuing our work with CPSI to bring this technology to the clinic.”
CPSI has been actively working on the development of the FrostBite™ cryocatheter for several years. FrostBite™ is designed to be used in conjunction with CPSI’s patented cryoengine technologies to freeze (cryoablate) cancer in situ (in place within the body), thereby destroying a tumor. This new device and approach is designed to support the growing field of natural orifice transluminal endoscopic surgery (NOTES) in which “scarless” abdominal operations can be performed with an endoscope passed through the mouth thereby enabling the introduction of surgical tools, such as CPSI’s cryoprobe, into the stomach to target various tissues via the stomach wall avoiding the need for invasive external surgical procedures. In this manner, FrostBite™ is designed to be introduced to the stomach via an endoscopic ultrasound (EUS) device and then the cryoneedle tip of the catheter passes directly through the stomach wall into a tumor in the pancreas. The use of EUS allows for the real-time visualization of the tumor and positioning of the cryoneedle prior to cryoablative treatment.
The initial development efforts behind FrostBite™ were supported, in part, by a Phase I SBIR grant awarded to CPSI by NCI in 2015. Phase I studies demonstrated proof of concept of this new technology and treatment paradigm and yielded the development of several prototype cryocatheters. As part of Phase I development efforts, CPSI, in conjunction with collaborators at Johns Hopkins Medical, conducted a series of studies demonstrating the successful delivery of an ultra-cold (<-170°C), highly effective lethal insult (ablative dose) within a matter of minutes. Phase 1 studies also involved collaborative efforts with researchers from the Institute of Biomedical Technology at Binghamton University. Successful completion of Phase I studies enabled CPSI to pursue Phase II funding. Phase II will build upon this success and focus on further development, optimization and testing of FrostBite™ for the treatment of pancreatic cancer as well as other gastroenterological (GI) based cancers. Speaking to the Phase II, Dr. Baust noted “this is a great opportunity to continue the development of the FrostBite™ platform for the GI-based treatment of various cancers. This Phase II will allow for continued engineering and testing of the next generation FrostBite™ cryocatheter. This project incorporates several of CPSI’s patented technologies, including our cryoengines, dual thermal ablation and adjunctive agents (SensitICERs). With success, FrostBite™ will provide an advanced minimally invasive approach for treating pancreatic and other cancers.” With Phase II development initiated, CPSI is poised to embark down the commercialization path. To enable this, a start-up company (GI Cryo, Inc.) has been formed focused in the GI area to commercialize FrostBite™ and other related technologies. To this end, Baust commented “We are actively seeking investors and partners to join our team to bring this potentially lifesaving technology platform to the market.”
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